Research
Overview
Dr. Zheng's research is centered on advancing our understanding of Thrombotic Microangiopathy (TMA), a group of rare but severe thrombotic disorders, and developing new targeted therapeutic approaches using animal models of TMA. He primarily employ zebrafish and mouse models to identify and characterize novel genetic factors and pathways involved in the pathogenesis of TMA. In addition, he is interested in exploring the role of environmental factors in modulating the disease onset, progression, and outcome.
- The function of ANKRD26 and its role in megakaryopoiesis and thrombocytopenia, NIDDK Cooperative Centers of Excellence in Hematology, PI
- Career Development Award, American Heart Association , PI
- Ankrd26, Thrombocytopenia 2 and TTP, National Blood Foundation , PI
- Zebrafish Models of Thrombocytopenia , National Institute of Genetics, Japan, PI
- Zheng, Liang , Cao, Liyun , Zheng, X. Long. 2022. ADAMTS13 protease or lack of von Willebrand factor protects irradiation and melanoma-induced thrombotic microangiopathy in zebrafish. Journal of Thrombosis and Haemostasis, 20 (10), 2270-2283
- Zheng, Liang , Zheng, X. Long . 2022. Animal models for thrombotic thrombocytopenic purpura: a narrative review. Annals of Blood.
- Zheng, L, Abdelgawwad, M., S, Zhang, D, Xu, L, Wei, S, Cao, W, Zheng, X., L. 2020. Histone-induced thrombotic thrombocytopenic purpura in adamts13-/- zebrafish depends on von Willebrand factor.. Haematologica, 105 (4), 1107-1119
- Zheng, L, Zhang, D, Cao, W, Song, W., C, Zheng, X., L. 2019. Synergistic effects of ADAMTS13 deficiency and complement activation in pathogenesis of thrombotic microangiopathy.. Blood, 134 (13), 1095-1105
- Zheng, Liang, Mao, Yingying, Abdelgawwad, Mohammad ., S , Kocher , Nicole , Li, Mandy, Dai, Xiangrong, Li, Benjamin , Zheng, X. Long. 2016. Therapeutic efficacy of the platelet glycoprotein Ib antagonist anfibatide in murine models of thrombotic thrombocytopenic purpura. Blood advances , 1 (1), 75-83
- Zheng, Liang , Hill, Jake , Zheng, Lucy , Rumi , M A Karim, Zheng, X. Long. 2022. A Simple, Robust, and Cost-effective Method for Genotyping Small-scale Mutations. Journal of clinical and translational pathology , 2 (3), 108-115.
