In a sort of BFF love triangle, Alyssa Milano wasn't comfortable sharing her bestie, Holly Marie Combs, with Shannen Doherty. At least, that's how Doherty described it on her podcast, "Let's Be Clear With Shannen Doherty." Combs had to undergo a tumor removal procedure not long after the first season of "Charmed" started filming, landing her in the hospital for a few days of recovery. But when Doherty went to wish her well, she reportedly was blocked by Milano and her mother. She explained, "I was being told I couldn't even get in by Alyssa and her mom. They were blocking people from seeing you but at the time, you didn't know."
Doherty then was in the awkward position of trying to maintain a friendship and a working relationship, confessing her sadness, but "I also felt like my anger at the situation of not being allowed to come see you, and how sort of family had swooped in and caused this sort of weird divide between the two of us." After that encounter, it was all downhill, with Doherty stating that every day on set left her in tears until she left "Charmed" in 2001.
Initially, Milano disagreed, telling Entertainment Weekly that it was their differing personalities; she was chill, and Doherty was strong-willed, that caused the rift, though she eventually saw Doherty's point of view, admitting to Entertainment Tonight in 2021, "I was in competition rather than it being that sisterhood."